妊娠合并细菌性阴道病的治疗对早产的影响

Impact of Treatment for Bacterial Vaginosis on Prematurity

目的评估治疗低危孕妇细菌性阴道病对预防早产及其他围产期并发症的影响。方法研究285例低危孕妇的细菌性阴道病检查结果,将她们分为三组,无细菌性阴道病组210例,合并细菌性阴道病予甲硝唑治疗组49例,合并细菌性阴道病未治疗组26例,追踪观察各组孕妇早产发生情况。结果在无合并细菌性阴道病组早产发病率为5.5%,合并细菌性阴道病给予治疗组为3.7%,未治疗组为22.5%,且未治疗组围产期并发症(未足月胎膜早破、早产等)明显较高。结论细菌性阴道病是早产原因之一,治疗细菌性阴道病,可能减少早产及围产期并发症的发生。

Objective The objective of this study was to evaluate the impact of treatment for bacterial vaginosis on a low-risk population of pregnant women, in order to prevent prematurity and other perinatal complications. Methods Vaginal bacterioscopy results from 285 low-risk pregnant women were studied. Three different groups of women were identified： 210 without bacterial vaginosis during pregnancy, 49 with bacterial vaginosis treated using metronidazole during pregnancy, and 26 with bacterial vaginosis not treated during pregnancy. The occurrence circumstance of each pregnant woman in premature were followed up and observed. Results The frequency of prematurity was 5.5% among the women without bacterial vaginosis, 22.5% among those with untreated bacterial vaginosis and 3.7% among those with treated bacterial vaginosis. The perinatal complications were significantly higher in the group with untreated bacterial vaginosis： premature rupture of membranes; preterm labor. Conclusion Bacterial vaginosis is one of the premature reasons. The treatment of bacterial vaginosis may possibly reduce the rates of prematurity and other perinatal complications.