新生儿缺氧缺血性脑病综合干预治疗与预后分析

Analysis of integrated intervention and prognosis for infants' hypoxic-ischemic encephalopathy(HIE)

目的探讨综合干预对中重度新生儿缺氧缺血性脑病(HIE)预后的影响。方法将102例中重度HIE患儿分为综合干预组54例和对照组48例。干预组新生儿期开始予抚触,运动,视觉听觉等干预刺激,高压氧,脑细胞代谢激活剂等药物干预治疗。两组病例均于出生后每隔3个月进行智能发育商检测并进行预后评估,随访。结果智能发育量表检测表明,干预组在3、6、9、12、24个月龄时DQ明显高于对照组。干预组预后良好率(88.89%)优于对照组(70.83%)。延长疗程,后续治疗尤其对重度HIE防治伤残十分重要。结论对中重度缺氧缺血性脑病早期给予综合干预能有效地促进其智能发育并改善预后。

Objective Investigation on the prognosis of integrated intervention for severe and moderate hypoxicischemie encephalopathy. Methods 102 patients with severe and moderate HIE were divided into integrated intervention group （54 cases）, and control group （ 48 cases）. The infants in the intervention group received intervention stimulations, such as ： touches, sports, visual and audio etc, and drug intervention, as hyperbaric oxygen and activator of brain cells metabolism. After their birth, intelligent development was tested, and prognostic evaluation and follow-up were made. Results Intelligent development tests indicated that the cases in the intervention group at the age of the months of 3,6,9, 12,24 had a higher DQ than those in the compared group. The prognosis rate of ＂satisfactory＂ in the intervention group was eighty （88.89%） ,higher than that of the compared group （70. 83% ）. It is very important for the cases with severe HIE to receive prolonged treatment and subsequent treatment to prevent disability. Conclusions An early integrated intervention for moderate and severe hypoxicischemic encephalopathy can effectively promote the intelligent development and improve the prognosis.