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阿德福韦酯联合α1b干扰素治疗慢性乙型肝炎疗效观察

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摘要 目的:了解阿德福韦酯联合α1b干扰素对慢性乙型肝炎的抗病毒治疗效果。方法:选择52例慢性乙型肝炎患者(治疗组)采用阿德福韦酯和α1b干扰素联合治疗,26例慢性乙型肝炎患者(对照组)单用α1b干扰素治疗。结果:治疗组HBVDNA转阴率与HBeAg转换率较对照组均有明显提高,差异有统计学意义。结论:阿德福韦酯联合α1b干扰素抗乙型肝炎病毒疗效优于单一用药。
出处 《中国医药导报》 CAS 2009年第32期38-39,共2页 China Medical Herald
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  • 1翁心华.乙型肝炎的自然史:对抗病毒治疗的启示[J].中华传染病杂志,2005,23(S1):16-18. 被引量:5
  • 2梁晓峰,陈园生,王晓军,贺雄,陈丽娟,王骏,林长缨,白呼群,严俊,崔钢,于竞进.中国3岁以上人群乙型肝炎血清流行病学研究[J].中华流行病学杂志,2005,26(9):655-658. 被引量:967
  • 3Chinese Society of Hepatology and Chinese Society of Infectious Diseases,Chinese Medical Association. 42 Dongsi Xidajie,Beijing 100710,China.慢性乙型肝炎防治指南[J].中华肝脏病杂志,2005,13(12):881-891. 被引量:1931
  • 4曾民德,茅益民,姚光弼,周霞秋,王豪,徐道振,姚集鲁,侯金林,王宇明,任红,陈亚岗,牛俊奇,王耀宗.阿德福韦酯治疗HBeAg阳性的中国慢性乙型病毒性肝炎患者52周的多中心临床研究[J].中华传染病杂志,2005,23(6):387-394. 被引量:164
  • 5Cullen JM,Li DH,Brown C,et al.Antiviral efficacy and pharmacokinetics of oral adefovir dipivoxil in chronically woodchuck hepatitis virus-infected woodchucks.Antimicrob Agents Chemother,2001,45:2740-2745.
  • 6Peters MG,Hann Hw H,Martin P,et al.Adefovir dipivoxil alone or in combination with lamivudine in patients with lamivudine-resistant chronic hepatitis B.Gastroenterology,2004,126:91-101.
  • 7Korba BE, Gerin JL. Antisense oligonucleotides are effective inhibitors of hepatitis B virus replication in vitro. Antiviral Res 1995; 28: 225-242
  • 8Bartholomew RM, Carmichael EP, Findeis MA, Wu CH, Wu GY. Targeted delivery of antisense DNA in woodchuck hepatitis virus-infected woodchucks. J Viral Hepat 1995; 2: 273-278
  • 9Weinberg M, Passman M, Kew M, Arbuthnot P. Hammerhead ribozyme-mediated inhibition of hepatitis B virus X gene expression in cultured cells. J Hepatol 2000; 33: 142-151
  • 10Davis HL, Michel ML, Whalen RG. DNA-based immunization induces continuous secretion of hepatitis B surface antigen and high levels of circulating antibody. Hum Mol Genet 1993; 2: 1847-1851

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