缺血性脑血管病患者血浆溶血磷脂酸的检测临床意义研究

目的探讨缺血性脑血管病与溶血磷脂酸(LPA)的关系。方法采用有机溶剂抽提,进一步分离出溶血磷脂酸,以定磷方法测定。结果短暂性脑缺血发作(TIA)组溶血磷脂酸水平最高(5.39±1.32)mol/L,脑梗塞组溶血磷脂酸次之(4.31±1.13)mol/L,对照组溶血磷脂酸(2.13±0.67)mol/L。结论溶血磷脂酸是体内疑血和血栓形成过程早期释放的分子标记物,可作为缺血性脑血管病的预警因子。

Objective To explore the relationship between lysophosphatidic acid （LPA） content and ischemic cerebrovascular disease. Methods Phospholipid was extracted from the patients＇ plasma by organic solvent, the LPA was isolated further, and the guantity of LPA was determined by assaying its phosphorous component. Results The content of LPA （5.39± 1.32） for transicent ischemic attacks （TIA） was the highest, while the content ofLPA （4.31±1.13） for cerebral infarction was followed by the content of LPA （2.13±0.67） on the control group. Conclusion LPA was a molecular marker released by activated platelets in vivo and pre-warning factor of ischemic cerebrovascular.