超声消融剂量与生物学焦域特征

Characteristics of Biologic Focal Region and Sonication Dosimitry

目的了解超声消融剂量与其产生的生物学焦域特征之间的关系。方法以JC型聚焦超声肿瘤治疗系统(治疗头频率1.6MHz)定点辐照方式消融离体牛肝组织,消融深度固定为20mm。声功率为60～200W,对应每级声功率,消融时间分别为1～20s。相同剂量重复3次。消融毕观察靶区形态特征,测量坏死区域长、宽径,计算形态指数和面积。结果生物学焦域形态具有多样性,形态指数随消融剂量增大而变小。生物学焦域与超声消融剂量之间存在正相关关系(y=0.0164X1.0591,R2=0.9238,P<0.05)。结论了解超声消融剂量与生物学焦域之间的关系有利于消融过程中选择消融剂量。

Objective To explore the relationship between the characteristics of biologic focal region （BFR） and sonication dose. Methods Material and methods Bovine liver in vitro was sonicated by JC-type focused ultrasound tumor therapeutic system. The exposure time was from 1 to 20 seconds with each acoustic power （frequency ： 1.6MHz, depth ： 20mm, acoustic power： 60-200W, 20W increased/time ） Results The index of BFR was decreased with ultrasound dosage increasing and there was positive correlation between the area of BFR and the HIFU dosage （ y=0.0164X1.0591,R2=0.9238,P 〈 0.05）. Conclusion Understanding the relationship between the characteristic of BFR and sonication dosage is helpful to choose a suitable dosage to get a good biologic focal region.