低载量乙肝病毒表面标志物模式的分布情况

The relationship between Hepatitis B surface marker pattern and low levels of Hepatitis B viral load

目的分析HBV DNA病毒低载量与乙肝表面标志物模式的分布情况。方法用实时荧光定量PCR测定乙肝病毒的载量;EIA检测乙肝标志物五项指标。结果 HBeAg表达较HBV DNA复制有滞后性。结论 HBeAg转阴是病毒低复制的标志,是肝细胞中活跃复制病毒的清除期;同时各类抗体的出现并不能排除乙肝病毒的低载量复制。

Objective To analyse the relationship between Hepatitis B surface marker pattern and low levels of hepatitis B viral load. Methods Hepatitis B viral load and Hepatitis B surface marker were detected by Real - time fluorescence quantitative PCR and EIA respectively. Results HBeAg expression was later than the replication of HBV DNA. Conclusion HBeAg seroconversion was a sign of the virus with low replication. It was the clearance phase of active replicated virus in liver ceils. HBV low expression could not be exclued despite the emergence of various types of antibodies.