藏药短尾铁线莲化学成分研究

Study on the Chemical Constituents from Clematis brevicaudata

目的:对藏药短尾铁线莲的化学成分进行系统研究。方法:利用硅胶柱色谱和制备薄层色谱等方法进行分离、纯化,并经核磁共振、质谱等现代波谱技术确定其结构。结果:从短尾铁线莲的95%乙醇室温提取物中获得了15个化合物,利用波谱技术鉴定了其中8个化合物的结构,分别为:棕榈酸(1)、二十二烷醇(2)、二十五烷酸-α-单甘油酯(3)、β-谷甾醇(4)、胡萝卜苷(5)、对羟基反式肉桂酸直链烷基酯类混合物(6)、3,4-二羟基反式肉桂酸乙酯(7)、丁香树脂单-β-D-葡萄糖苷(8)。结论:这些化合均为首次从该植物中获得。

Objective：To study the chemical constituents from Clematis brevicaudata. Methods ：The compounds were isolated by column chromatography and their structures were elucidated through spectroscopic analysis（NMR）. Results：Eight compounds were iso- lated and identified as ： palmitic acid （ 1 ）, 1 -docosanol（ 2 ）, pentacosanoic acid-2＇, 3 ＇-dihydroxypropyl ester（ 3 ） ,β-sitosterol（4 ）, dancosterol （5）, a mixture of the trans-p-coumarate of the n-alkanols （6）, 3,4-dihydroxy-trans coumatate ethyl ester（ 7 ）, syringaresinol-O-D-glucopyranoside（ 8 ）. Conclusion： All these compounds are obtained from Clematis brevicaudata for the first time.