摘要
目的:分离鉴定仙鹤草降糖活性部分的化学成分。方法:采用硅胶柱、Sephadex LH-20柱等常压柱色谱手段进行分离纯化,通过理化常数和光谱分析鉴定其结构。结果:从仙鹤草中分得9个化合物,并鉴定为芹菜素-7-O-β-D-葡萄糖苷(1)、儿茶素(2)、槲皮素(3)、芦丁(4)、山奈酚-3—O-α-L-鼠李糖苷(5)、山奈酚-3—O-β-葡萄糖苷(6)、木犀草素-7—O-β-D-葡萄糖苷(7)、19α,24-二羟基乌苏酸(8)、3,3’-二甲基鞣花酸-4-O-β-D-吡喃葡萄糖苷(9)。结论:化合物1、7—9均为首次从该植物中分离得到。
Objective: To isolate and identify the chemical constituents from the active section lowering blood sugar of agrimony. Methods : The compounds were separated by repeated silica gel, Sephadex LH-20 and HPLC chromatographies. The structures of compounds isolated were identified by analysis of their spectral data and chemical properties. Results : Nine compounds were isolated from the active section with lowering blood sugar of agrimony and their structures were identified as apigenin-7-O-β-D-glueopyranoside( 1 ), eateehin ( 2 ), quercetin ( 3 ) , rutin ( 4 ) , kaempferol-3-O-α-L-rhamnoside ( 5 ) , Kampferol-3-O-β-D-glucopyranoside ( 6 ) , luteolin-7-0-β- D-glucopyranosidc ( 7 ), 19α, 24-dihydroxy ursolic acid ( 8 ), 3,3 '-di-O-rnethyl ellagie acid-4-O-β-D-glueopyranoside (9). Conclusion : Compounds 1,7,8,9 are isolated from thia plant for the first time.
出处
《中药材》
CAS
CSCD
北大核心
2009年第10期1537-1539,共3页
Journal of Chinese Medicinal Materials
关键词
仙鹤草
降糖
活性成分
Agrimony
Lowering blood sugar
The active substance