摘要
设计合成了2个透明质酸(HA)模拟物1和2,通过最小基团M eO的引入修饰,模拟天然HA片段的特性,用于透明质酸合成酶(HAS)催化机理与抑制剂的研究.
The syntheses of two hyaluronan trisaccharide analogues, naphthyl O-( 3-methoxy-β-D-glucopy- ranosyluronie acid ) - ( 1,3 ) -O- ( 2-aeetamido-2-deoxy-β-D-glueopyranosyl ) - ( 1,4 ) -O-β-D-glueopyranosyluronie acid and naphthyl O- ( 3-methoxy-2-acetamido-2-deoxy-β-D-glucopyranosyl ) - ( 1,4 ) -O- (β-D-glucopyranosylu- ronie acid)-( 1,3)-O-2-acetamido-2-deoxy-β-D-glucopyranoside, were described. Construction of the target molecules was achieved through a combination of BF3 .Et2 O/toluene system and trichloroaeetimidate glyeosylation methodology. This is the first report on the synthesis of the 3-methoxyl derivatives, which represent the smallest fragments that incorporate all the structural features of polymeric hyaluronan and can be used for potential hyaluronic acid synthases inhibitors.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2009年第11期2199-2203,共5页
Chemical Journal of Chinese Universities
基金
国家自然科学基金(批准号:30701043)资助