乙型病毒性肝炎核心抗体阳性对肾移植患者影响的临床研究

The influence of anti-HBc antibody on patients after renal transplantation

目的探讨乙型肝炎核心抗体(HBcAb)对于肾移植患者的影响。方法观察不同乙型病毒性肝炎(乙型肝炎)标志物[A组(乙型肝炎表面抗原HBsAg+,HBcAb+),B组(HBsAg-,HBcAb+),C组(HBsAg-,HBcAb-)]组间肾移植患者肝功能、肾功能等指标间的差异。结果A组肝功能异常发生率52.0%,B组肝功能异常发生率36.8%,C组肝功能异常发生率8.69%,三组间比较均有显著差异。结论肾移植患者合并单纯乙型肝炎核心抗体阳性肝功能异常发生率仍较高。

Objective To study the influence of anti-hepatitis B core antigen antibody （HBcAb） on renal transplantation patients. Methods Patients were divided into 3 groups based on the markers for hepatitis B virus infection： Group A （HBsAg＋ and HBcAb＋）, Group B （HBsAg- and HBcAb＋）, and Group C （HBsAg- and HBcAb-）. Liver damage and kidney function were analyzed among the 3 groups after renal transplantation. Results The incidence of liver damage was 52.0% in group A, 36.8% in group B, and 8.69% in group C. Significant differences were found among the 3 groups. Conclusions Liver damage is frequently seen in patients with positive HBcAb after transplantation.