医用葡聚糖包被超顺磁性纳米氧化铁磁珠的制备和表征

Preparation and Characterization of Dextran Coated Superparamagnetic Iron Oxide Nanoparticles for Medical Applications

纳米磁性颗粒因其独特的性能,在基础研究领域和临床诊断上已经得到广泛应用,比如细胞分离、免疫识别、药物载体以及核磁共振成像阴性对比剂等。本文主要利用化学共沉淀的方法,制备了一种可以在交变磁场中升温的纳米氧化铁水基磁流体。利用正交实验分析了磁珠粒径与实验条件(氨水、铁盐和葡聚糖用量及反应温度)之间的关系。利用各种方法对粒径大小、磁珠的粒径分布及其形貌进行分析;确定葡聚糖外壳与氧化铁内核之间的关系;测定了样品的磁学特性。结果显示,该方法制备的水基葡聚糖包被氧化铁磁流体在室温下具有很好的稳定性,状态可以数月内不发生任何改变。

Nano magnetic particles are extensively used in both clinical diagnostics and basic researches for its distinct features, such as cell separation, immune recognition, contrast reagents in Magnetic Resonance Imaging （MRI）. This paper proposes a method of preparing magnetic nanoparticles in the aqueous phase, which can be heated in an alternating magnetic field. Through orthogonal experiments, the relationship between particle diameter and reaction condition （dose of ammonia, iron salt, dextran and temperature） is optimized. The size of magnetic nanoparticles and their distribution, the relationship between dextran shell and iron oxide core, the magnetic characteristics are measured. The dextran coated iron oxide nanoparticles prepared in this way can be stored in room temperature for several months without any change of properties.