小剂量、短疗程甲孕酮减轻化疗胃肠道反应的研究

The efficacy of medroxyprogesterone acetate on chemotherapy-induced gastrointestinal reactions

目的观察小剂量、短疗程的醋酸甲羟孕酮(MPA)能否减轻化疗胃肠道反应。方法77例恶性肿瘤患者随机分为AB和BA两组。AB组在第1周期化疗前一天开始口服MPA 250mg/d,连续5天,同时使用5-羟色胺(5-HT3)受体拮抗剂(格拉司琼),第2周期单用格拉斯琼止吐。BA组MPA在第2周期口服。结果使用MPA后恶心、呕吐、食欲减退发生程度低于不用MPA,差异有统计学意义(P<0.05)。未发现病人血糖升高、血栓、水钠潴留等副作用,有5例绝经妇女出现阴道流血,占绝经女性5%。结论小剂量、短疗程甲孕酮联合5-HT3受体拮抗剂可以减轻化疗的胃肠道反应。

Objective The purpose was to investigate the efficacy of medroxyprogesterone acetate（ MPA）that prevent chemotherapy-induced gastrointestinal reactions. Methods 77 cancer patients were divided into two groups, inclu- ding AB and BA. In the first cycle of chemotherapy, the patients in AB group were treated with medroxyprogesterone acetate 250mg orally once a day 5 days before chemotherapy, but not administered in the second cycle. In the group, patients were treated with medroxyprogesterone acetate in the second cycle. Results The degree of appetite, nause and vomiting was significantly improved in the cycle that treated with medroxyprogesterone acetate （P〈0. 05）. There were some cases （5%） with postmenopausal vaginal bleeding, no case with thrombosis and edema.. Conclusion Short-term medroxyprogesterone acetate therapy can relieve the chemotherapy-induced gastrointestinal reactions.