环氧化酶-2在上皮性卵巢癌组织中的表达及其临床意义

Expression and clinical significance of Cyclooxygenase-2 in epithelial ovarian cancer

目的:探讨上皮性卵巢癌中环氧化酶-2(COX-2)的表达及临床意义。方法:采用链霉素抗生物素卵白素-过氧化物酶(SP)法进行免疫组化染色,观察COX-2在正常组织及良恶性上皮性卵巢癌组织中的蛋白表达,应用SPSS13.0软件结合病历资料进行分析。结果:正常组织及良恶性上皮性卵巢肿瘤中COX-2皆有表达,COX-2在卵巢癌组织中的阳性表达率78%(39/50)明显高于正常卵巢组织10%(1/10)及良性卵巢肿瘤组织20%(2/10),差异有统计学意义(P<0.01);在正常组织和良性卵巢肿瘤组织中的表达差异无统计学意义(P>0.05)。COX-2表达与病理分级及淋巴结转移明显相关(P<0.05),而与年龄、临床分期、组织学类型无关(P>0.05)。结论:COX-2在卵巢癌组织中的表达明显高于正常组织及良性卵巢肿瘤组织,在卵巢癌的浸润和转移中发挥了重要作用,可以作为判断卵巢癌恶性程度及评估不良预后的重要指标。

Objective：To investigate the expression of cyclooxygenase-2（COX-2） in epithelial ovarian cancer tissue,and understand its clinical significance.Methods：The expression of COX-2 were examined in epithelial ovarian cancer,benign ovarian neoplasm and normal tissue controls by immunohistochemical staining.Then the relationship between the expression of COX-2 in human ovarian epithelial cancer and its clinical pathologic parameters was aggregate analyzed by SPSS 13.0 software.Results：The expression of COX-2 in epithelial ovarian cancer 78%（39/50） was higher than that in normal ovarian tissue 10%（1/10）,the difference was statistically significance（P〈0.01）.The expression of COX-2 was correlated with histological differentiation,lymphnode metastasis and prognosis（P〈0.05）,but not with age,clinical stage and histological types（P〉0.05）.Conclusion：The expression of COX-2 in epithelial ovarian cancer is significantly higher than that in normal ovarian tissue and benign ovarian neoplasm,it plays a key role in progression and metastasis of epithelial ovarian cancer.The over expression of COX-2 may serve as an useful marker for assessment of the biological behavior of epithelial ovarian cancer and may helpful for assessing the malignancy prognosis.