轻度认知损伤重复效应脑电研究:范式及应用

Electrophysiological Measures of Repetition Effects in Mild Cognitive Impairment: Paradigm and Implication

"语义一致性加重复"范式(congruity-plus-repetition paradigm)在早前重复范式的基础上增加了早期语义情境用以控制重复效应的前期成份N400和后期成份P600之间的相互干扰。作者回顾了这种范式在轻度认知损伤(mild cognitive impairment,MCI)的事件相关电位研究领域的应用,并分析了该范式在MCI的识别及预测其向痴呆转归方面的优越性。提示效应的组合更能标记正常认知老化向痴呆的动态过渡;能产生两个或多个效应组合的实验范式将是该领域未来研究方向之一。

The congruity-plus-repetition paradigm is an exceeding paradigm from the traditional repetition paradigm, through adding semantic context in the beginning of each trial to control the interference between the early （N400） and late （P600） components. There are prominent advantages with this paradigm to be used in the filed of event-related potential （ERP） studies in mild cognitive impairment （MCI）, as it facilitated the performance of MCI by implicit nature of task while could explore both implicit and explicit memory components. The leading conclusions are that P600 repetition effect is impaired markedly in MCI, and N400 repetition effect is abnormal in MCI to some extent. Furthermore, the combination of these two effects deserves further consideration as a biomarker for monitoring the progressing from normal memory aging to MCI and to dementia, and paradigms yielding more than one cognitive process - related ERP effects need to be developed in this field.