摘要
大鼠原位肠-肝灌流模型被认为在研究药物的吸收、代谢和首过效应方面具有独特的优势。本文对该模型的方法、应用和前景进行综述。
Since pang set up the perfused rat intestine-liver preparation and applied it to study the disposition of enalapril, this model has been widely considered to have the particularly advantage in studying the absorption, metabolism and first-pass effect. Now the methods and applications are to be reviewed and the perspective is to be discussed.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2009年第21期2701-2703,共3页
China Journal of Chinese Materia Medica
基金
中医药行业科研专项(200807036)
中国中医科学院基本科研业务费自主选题项目(ZZ2006114)
关键词
肠-肝灌流
首过效应
perfused intestine-liver
first-pass effect
