异基因造血干细胞移植后巨细胞病毒感染的发病情况及疗效分析

The incidence and antiviral effect against cytomegalovirus infection after hematopoietic stem cell transplantation

目的:探讨异基因造血干细胞移植(allo-HSCT)后,巨细胞病毒(CMV)感染的发病情况及抗病毒治疗的疗效。方法:对在我所接受allo-HSCT的患者23例进行回顾性分析,均应用荧光定量PCR法(FQ-PCR法)检测外周血CMV-DNA含量。CMV感染应用更昔洛韦(GCV)10mg.kg-1.d-1进行治疗。结果:23例患者中7例移植后发生CMV感染,占30.43%。GCV治疗的总有效率约为85.71%。6例在GCV治疗过程中出现白细胞和血小板减少。结论:FQ-PCR法可以应用于allo-HSCT后早期准确诊断CMV感染。GCV对allo-HSCT后CMV感染的预防及治疗效果可靠。

Objective：To study the incidence and antiviral effect against cytomegalovirus（CMV） infection after allogeneic hematopoietic stem cell transplantation（allo-HSCT）.Method：Twenty-three patients who underwent allo-HSCT were enrolled in a retrospective study.In this study,we used fluorescence quantitative PCR（FQ-PCR） to examine the quantity of CMV-DNA in peripheral blood.When CMV infection was positive,10mg·kg-1·d-1ganciclovir was used for the treatment.Result：The incidence of CMV infection was 30.43%（7/23）.Effective rate of anti-CMV treatment was about 85.71%.Six patients with CMV infection occurred leukopenia and thrombocytopenia.Conclusion：FQ-PCR contributes to early and accurate diagnosis of CMV infection after allo-HSCT.Ganciclovir is effective for prophylaxis and treatment of CMV infection after allo-HSCT.