肺心病合并冠心病患者血栓前状态的研究

Study on Hemorheology in Prethrombotic States of Pulmonary Heart Disease Combined with Coronary Heart Disease

目的探讨肺心病合并冠心病患者血浆中血栓前体蛋白（TpP）、同型半胱氨酸（Hey）水平在早期诊断血栓前状态中的价值。方法检测肺心病合并冠心病患者血浆TpP、Hcy、DD指标，并与肺心病、冠心病、脑梗死及正常人对照。结果肺心病、冠心病、肺冠心及脑梗死患者Hcy、TpP、DD与正常人比较差异显著；脑梗死组患者TpP明显高于肺心病、冠心病及肺冠心组；肺心病、肺冠心和脑梗死患者的DD明显高于冠心病组；四组患者TpP和DD阳性率比较有差异，脑梗死组最高，肺冠心组其次。结论 T-Hcy、TpP、DD均可以作为早期诊断血栓形成前状态的分子标志物，在早期判断血栓前状态时具有较高临床价值。

Objective To study on the value of TpP and Hey to make an early diagnosis ofprethrombotic states in pulmonary heart disease combined with coronary heart disease patients.Methods Indices of TpP,Hcy and DD were observed in pulmonary heart disease combined with coronary heart disease,pulmonary heart disease,coronary heart disease,cerebral infarction patients-and normal subjects respectively.Results TpP, Hcy, DD of four groups were much higher than that of normal subjects.The level of TpP of cerebral infarction patients was higher than pulmonary heart disease combined with coronary heart disease,pulmonary heart disease,coronary heart disease patients.To compare with coronary heart disease patients,the levels of DD of pulmonary heart disease combined with coronary heart disease, pulmonary heart disease, cerebral infarction patients were much higher.Conclusion TpP, Hcy and DD can be used to make an early diagnosis of Drethrombotic states in patients.