AgNOR变化在唾腺肿瘤中的诊断学意义

The Diagnostic Significance of AgNOR Alteration in the Salivary Gland Tumors

应用AgNOR染色技术,对48例良、恶性唾腺肿瘤,慢性唾腺炎和正常唾腺组织手术切除标本中的细胞核内AgNOR的数量、大小、形状和分布规律进行观察与对比分析。结果表明,炎症组(I组)腺泡上皮细胞内的AgNOR均数(x±SD=1.41±0.13)与正常组(N组)的均数(x±SD=1.39±0.12)无明显差异(P>0.05),而良性肿瘤组(B组)与恶性肿瘤组(M组)两组瘤细胞内的AgNOR均数(x±SD=2.69±0.29和4.82±2.22)之间以及各自与N组和I组相比较的结果,均有显著差异(P值均<0.01)。研究还表明,虽然AgNOR计数在良、恶性唾腺肿瘤之间还存在着一定数量的重叠病例,但AgNOR除了数目变化之外,还有大小、形状与分布上的不同。作者认为,将这几种变化综合分析,可能在区别某些肿瘤的良、恶性和分型、分级上具有更大的参考价值。

Nucleolar organizer region associated protein (AgNOR) technique was used to investigate the changes of nuclear AgNOR with the resected salivary gland specimens of 48 cases (normal gland 14, chronic adenitis 8, benign tumors 14, and malignant tumors 12) .It was found that, there was no significant difference of the mean number of the AgNOR between the chronic adenitis and normal group(x 1.41±0.13Vs. 1.39±0.12), but there were significant difference between benign and malignant groups, (x 2.69±0.29Vs. 4.82±2.22), between normal and chronic adenitis groups, between tumor groups each and normal group, and between each and adenitis groups (all the P value were <0.01). This study also showed that, although there were some overlap cases in the numbers of AgNOR between benign and malignant tumors, but there were some differences in the sizes, shapes, and distributions of AgNOR else. The authors suggested that, to summerize and analyse the changes AgNOR showed above, may give referential values in differentiating benign and malignancy, and in the typing and grading of the salivary gland tumosr.