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乙肝的生物治疗研究态势分析 被引量：3

Analysis on the Research Trends of Hepatitis B Biotherapy
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摘要 以科学引文索引(Science Citation Index Expanded,SCI-E)数据库为数据源,利用文献计量分析和文献引用分析方法,对乙肝生物治疗研究态势进行分析,从中总结乙肝防治研究的国家(地区)分布、机构分布和领域分布特点,发现提高siRNA的抑制效率是近年来乙肝生物治疗研究重点之一并就提高效率的研究方法进行分析。 The paper studies research trends in biotherapy of hepatitis B using bibliometrics and literature citation analysis based on the data from Science Citation Index Expanded, summarizes the country （region）, institute and research area distribution features of this field, and finds anti -HBV siRNA efficiency improving has became one of the important research areas in this field, then analyzes the methods for improving efficiency.
作者 陈大明
机构地区 中国科学院上海生命科学信息中心
出处 《医学信息学杂志》 CAS 2009年第10期50-53,共4页 Journal of Medical Informatics
关键词 乙型肝炎 生物治疗 RNA干扰 SIRNA 文献计量 文献引用树 Hepatitis B Biotherapy RNA interfering siRNA Bibliometric Literature citation tree
分类号 R512.62 [医药卫生—内科学]
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参考文献10

  • 1WHO Department of Communicable Diseases Surveillance and Response.WHO/CDS/CSR/LYO/2002.2:Hepatitis B. http://www.who.int/csr/disease/hepatitis/whocdscsrlyo20022/en/ . 2009
  • 2Suda T,Liu D.Hydrodynamic Gene Delivery:its principles and applications[].Molecular Therapy.2007
  • 3McCaffrey AP,Nakai H,Pandey K,et al.Inhibition of hepatitis B virus in mice by RNA interference[].Nature Biotechnology.2003
  • 4Ying C,De Clercq E,Neyts J.Selective inhibition of hepatitis B virus replication by RNA interference[].Biochemical and Biophysical Research Communications.2003
  • 5Konishi M,Wu CH,Wu GY.Inhibition of HBV replication by siRNA in a stable HBV-producing cell line[].Hepatology.2003
  • 6Giladi H,Ketzinel-Gilad M,Rivkin L,et al.Small interfering RNA inhibits hepatitis B virus replication in mice[].Molecular Therapy.2003
  • 7Morrissey D V,Blanchard K,Shaw L,et al.Activity of stabilized short interfering RNA in a mouse model of hepatitis B virus replication[].Hepatology.2005
  • 8Morrissey DV,Lockridge JA,Shaw L,et al.Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs[].Nature Biotechnology.2005
  • 9Wu,H. L.RNA interference-mediated control of hepatitis B virus and emergence of resistant mutant[].Gastroenterology.2005
  • 10Carmona S,Ely A,Crowther C,et al.Effective Inhibition of HBV Replicationin Vivo by Anti-HBx Short Hairpin RNAs[].Molecular Therapy.2006

同被引文献37

  • 1冯璐,冷伏海.共词分析方法理论进展[J].中国图书馆学报,2006,32(2):88-92. 被引量：564
  • 2Kettaneh A, Marcellin P, Douvin C, et al. Features Asso- ciated with Success Rate and Performance of FibroScan Measurements for the Diagnosis of Cirrhosis in HCV Pa- tients: a prospective study of 935 patients [ J]. J Hepatol, 2007, 46 (4): 628-634.
  • 3Lupsor M, Badea R, Stefanescu H, et al. Analysis of His- topathological Changes that Influence Liver Stiffness in Chro- nic Hepatitis C. Results from a Cohort of 324 Patients [ J]. J Gastrointestin Liver Dis, 2008, 17 (2) : 155 - 163.
  • 4Obara N, Ueno Y, Fukushima K, et al. Transient Elastog- raphy for Measurement of Liver Stiffness Measurement Can Detect Early Significant Hepatic Fibrosis in Japanese Patients with Viral and Nonviral Liver Diseases [ J). J Gastroenterol, 2008, 43 (9): 720-728.
  • 5Fung J, Lai CL, But D, et al. Prevalence of Fibrosis and Cirrhosis in Chronic Hepatitis B: implications for treatment and management [ J ]. Am J Gastroenterol, 2008, 103 (6) : 1421 - 1426.
  • 6Yoneda M, Yoneda M, Fujita K, et al. Transient Elastog- raphy in Patients with Nonalcoholic Fatty Fiver Disease (NAFLD) [J). Gut, 2007, 56 (9) : 1330 -1331.
  • 7Nguyen - Khac E, Chatelain D, Tramier B, et al. Assess- ment of Asymptomatic Liver Fibrosis in Alcoholic Patients U- sing FibroScan- prospective comparison with seven non -in- vasive laboratory tests [ J]. Aliment Pharmacol Ther, 2008, 28 (10): 1188-1198.
  • 8Sadrin L, Fourquet B, Hasquenoph JM. Transient Elastog-raphy: a new noninvasive method for assessment of hepatic fibrosis [J]. Ultrsound Med Biol, 2003, 29 (12): 1705 -1713.
  • 9Sik JK, Up KS, Hoon AS, et al. Spleen Stiffness Measure- ment Using FibroScan for the Noninvasive Assessment of E- sophageal Varices in Liver Cirrhosis Patients [ J]. Hepatolo- gy, 2011, 53 (3): 885-894.
  • 10Horia S, Mireea G, Mornica L, et al. Spleen Stiffness Measurement Using FibroScan for the Noninvasive Assess- ment of Esophageal Varices in Liver Cirrhosis Patients [ J ]. J Gastroenterol Hepatol, 2011, 26 ( 1 ) : 164 - 170.脏.

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医学信息学杂志
2009年 第10期

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