食管上皮内瘤变和癌组织中P15 P16的表达及其生物学意义

Expression and biological significance of P15 P16 protein in different procancerous lesion and esophageal squamous cell carcinoma tissue

目的检测食管上皮内瘤变及鳞癌组织中P15、P16的表达,探讨它们在食管癌发生、发展过程中的意义。方法收集山西省肿瘤医院病理科2003—2005年手术切除的食管鳞癌标本105例,病理复诊证实为食管鳞癌并伴有食管上皮内瘤变和正常食管鳞状上皮组织,用免疫组织化学S-P法检测P15、P16蛋白的表达。结果P15、P16蛋白在鳞癌组织中的表达明显低于食管上皮内瘤变和正常食管鳞状上皮组织(P<0.01)。结论P15、P16蛋白的失表达参与了食管癌的发生发展。

Objective To examine the expression of P15, P16 protein in different procancerous lesion and esophageal squamous cell carcinoma tissue and to investigate the relationship between their expression. Methods Immunohistochemistry was demonstrated to show these tumor markers＇ expression in different procancerous lesions and esophageal squamous cell carcinoma tissue. Results Stepwise reduction of P15, P16 protein expression were observed in the muti-step process of esophageal tissue. Significant difference in expression of these tumor markers （P〈0.01） was observed between normal esophageal epitbelia and dysplasia. Conehlsion Stepwise reduce expression of P15, P16 protein had relation with esophageal squamous cell carcinoma.