类固醇受体辅活化因子家族与乳腺癌
摘要
类固醇激素通过与包括ER、PR、AR、GR在内的类固醇受体结合而表现出生物学活性,在调控生长发育和多种生理机能方面起着至关重要的作用。与激素结合前,类固醇受体与辅阻遏因子结合以抑制目的基因的活性;与激素结合后,类固醇受体与辅阻遏因子解离并募集辅活化因子而获得翻译活性。所以,类固醇受体辅活化因子(steroid receptor coactivator,SRC)家族在这一过程中起重要作用。
出处
《中华乳腺病杂志(电子版)》
CAS
2007年第1期48-51,共4页
Chinese Journal of Breast Disease(Electronic Edition)
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