支气管哮喘患者血浆可溶性白介素-2受体水平与气道炎症关系的研究

Relationship between soluble interleukin-2 receptor and inflammation in bronchus of patients with asthma

目的探讨支气管哮喘患者血浆中可溶性的白介素2受体(soluble interleukin-2 receptor,sIL-2R)和气道黏膜的炎症程度的关系。方法采用ELISA法检测15例哮喘患者和15例健康对照者血浆中sIL-2R,并对支气管黏膜活检标本的炎症细胞定量计数。结果哮喘患者血浆中sIL-2R水平明显高于正常对照组[(47.47±13.29)U/ml,(31.59±4.00)U/ml,P<0.05]。哮喘患者的血浆sIL-2R水平与支气管上皮层内嗜酸粒细胞数呈正相关(r_s=0.82,P<0.05),与炎症细胞总数呈正相关(r_s=0.75,P<0.05)。结论 sIL-2R与哮喘气道炎症相一致,可用于监测气道炎症的活动性。

Objective To investigate the relationship between soluble interleukin 2 receptor（sIL-2R） and inflammatory degree in the patients with asthma. Methods Fifteen asthmatic patients and 15 normal subjects were recruited and the concentration of sIL-2R was measured by ELISA, the inflammatory cells in the mucous of bronchus were recorded. Results The serum level of sIL-2R in asthmatic patients was significantly higher than normal subjects（47.47±13.29） U/ml vs V （31.59±4.00） U/ml, （ P〈0.0.5）. The concentration of sIL- 2R showed a significantly positive correlation with the counts of eosinophils and total inflammatory cells in the epithelium （ rs= 0.82, P 〈 0.05; rs = 0.75, P 〈0.05）. Conclusions The concentration of sIL-2R is correlated with inflammatory cells in the mucous of bronchus and can be used as a nonJnvasive index of the activity in bronchial inflammation.