中风中经络和中脏腑患者的脑脊液H^+浓度和气体变化的分析

Analysis of changes in cerebral spinal fluid pH and gas in stroke patient with Zhong Jingluo and Zhong Zangfu

目的：探讨中风患者中经络、中脏腑的脑脊液酸碱度和气体变化的关系，揭示中经络和中脏腑的不同病理本质，为临床诊断和治疗中风提供依据。方法：用血气分析仪对１００例中风患者做了脑脊液酸碱度的测定和气体分析。将中经络组、中脏腑组分别与５１例正常对照组和５１例脑脊液对照组比较。结果：中脏腑组与中经络组氢离子浓度（Ｈ＋）均显著增高（Ｐ均＜０．０１），以中脏腑组更明显。中脏腑组剩余碱（ＢＥ）、标准碳酸氢根（ＳＢ）和标准剩余碱（ＳＢＥ）３项指标显示代谢性酸中毒与正常对照组和中经络组比较均有显著性差异（Ｐ＜０．０１和Ｐ＜０．０５）。结论：脑脊液中Ｈ＋增高是中风的危险因素。脑脊液代谢性酸中毒是中脏腑患者的生化物质基础；脑脊液有否代谢性酸中毒是判断中经络、中脏腑患者的客观指标之一，为中风病的诊断。

Objective:To investigate the relationship of changes in cerebral spinal fluid (CSF) pH and gas in stroke patients with Zhong Jingluo and Zhong Zangfu ,then to explore the different pathologic character of Zhong Jingluo and Zhong Zangfu,so that to provide the basis of clinical diagnosis and treatment.Methods:The CSF pH level and gas were measured by blood gas analyzer in 100 cases of stroke,then the Zhong Jingluo group and Zhong Zangfu group were compared with normal control group ( n =51) and CSF control group ( n =51).Results:There was raised obviously of hydrogen ion concentration in Zhong Zangfu group and Zhong Jingluo group (both P <0 01),particulary in Zhong Zangfu group.The level of base excess (BE),standard bicarbonate (SB) and standard base excess (SBE) in Zhong Zangfu group showed that present metabolic acidosis,it has obvious difference with normal control group and Zhong Jingluo group ( P <0 01 and P <0 05).Conclusions: Increase of CSF hydrogen ion concentration is a danger factor of stroke;metabolic acidosis in CSF is a material basis of biochemistry and objective index of judging patients with Zhong Jingluo and Zhong Zangfu,it can provide the objective fundation to diagnosing,treating and prognosing the stroke.