表皮生长因子受体在卵巢浆液性肿瘤中表达的研究

Study on the expressions of epidermal growth factor receptor in ovarian serous tumours.

目的：研究表皮生长因子受体在卵巢浆液性肿瘤中的表达，并探讨其表达与肿瘤的性质、临床分期及组织学分级的关系。方法：用免疫组化ＡＢＣ法。结果：表皮生长因子受体在卵巢浆液性腺癌和浆液性交界性瘤中的表达差异无显著性，但均显著高于其在腺瘤中的表达。表皮生长因子受体的表达与卵巢浆液性腺癌的临床分期无关，在低分化腺癌中的表达显著高于中分化腺癌。结论：表皮生长因子受体在卵巢浆液性腺癌的发生发展过程中起着重要作用。

Objectives:To research the expressions of epidermal growth factor receptor (EGFR) in ovarian serous tumours and to study the relations between EGFR status and the character of tumours,histological grades,clinical stage.Methods:A total of 43 samples of OST were tested using immunohistochemical ABC method .Results:There was no significant difference in expressions of EGFR between ovarian serous adenocarcinoma (OSADC) and serous borderline tumours.But both expressions of EGFR in OSADC and serous borderline tumours were significantly higher than that in OST.There was also no relationship between the expression of EGFR and clinical stages.The expression of EGFR in low differentiated adenocarcinoma was higher than that in middle differentiated adenocarcinoma.Conclusion:EGFR is important in the genesis and development of ovarian serous adenocarcinoma and can be used as an index to define the degree of malignancy of tumours.