疏血通注射液与氯吡格雷联合治疗急性脑梗死临床观察

Clinical Observation of Clopidogrel Combined with Injectio Shuxuetong on Acute Cerebral Infaction

目的:观察中西医结合疗法联合治疗急性脑梗死患者的临床疗效及其对血液流变学的影响。方法:将160例急性脑梗死患者随机分为两组各80例,两组均予脑梗死急性期基础治疗,其中对照组氯吡格雷75mg口服,每日1次,治疗组氯吡格雷75mg口服,疏血通10mL静脉滴注,两组均连续治疗15天。结果:治疗组基本治愈38例,显著进步22例,进步12例,无效8例,总有效率为90.0%;对照组基本治愈16例,显著进步18例,进步20例,无效26例,总有效率为67.5%。治疗组总有效率优于对照组,两组疗效有显著性差异(P<0.05)。治疗组全血黏度、血浆黏度、纤维蛋白原指数均明显下降(P<0.01),无特殊不良反应。结论:疏血通与氯吡格雷联合治疗能提高临床疗效,改善血液流变学,降低血液黏稠度,优于单纯西药治疗。

Objective ：To observe the clinical effect of clopidogrel combined with Injectio Shuxuetong on acute cerebral infarction and haemorheology. Method： 160 cases with acute cerebral infarction were divided into two groups randomly, 80 cases in each group. The two groups were treated all by conventional therapy on acute cerebral infarction. Besides it the control group was treated with clopidogrel,75 mga day and once taking orally, and the cases were recovered,22 ones excellent, 12 ones effective and 8 ones ineffective. The total effective rate was 90%. In control group 16 cases were recovered, 18 ones excellent,20 ones effective and 26 ones ineffective. The total effective rate was 66%. There was significant difference on total effective rate between two groups （ P 〈 0. 05 ）. It showed a dramatic descend in whole blood viscosity, blood plasma viscosity and fibrinogen （P 〈 0. 01 ）. And no adverse effect occurred. Conclusion：Injectio Shuxuetong combined with clopidogrel has good and reliable effect on acute cerebral infarction. The method can improve haemorheology and decline blood viscosity and is superior to single medicinal treatment.