摘要
目的探讨放射性核素骨显像(ECT)与肿瘤标志物CEA、NSE和CYFRA21-1检测在肺癌骨转移诊断中的价值。方法对263例肺癌患者进行单光子发射计算机断层仪(SPECT)全身骨显像的同时,采用罗氏电化学发光免疫系统检测其血清CEA、CYFRA21—1、NSE肿瘤标志物水平。结果ECT联合CEA+NSE+CYFRA21—1检测和ECT诊断肺癌骨转移的敏感性、特异性、准确性分别为88.9%(152/171)和65.5%(112/171)、96.7%(89/92)和87.0%(80/92)、91.6%(241/263)和73.0%(192/263),ECT联合CEA+NSE+CYFRA21—1检测优于单独SPECT检查(P〈0.01)。结论核素骨显像与肿瘤标志物联合检测在肺癌骨转移诊断中有较高,临床价值。
Objective To evaluate the value of tumor markers ( CEA NSE CYFRA 21 - 1 ) and ECT in diagnosis of bone metastasis in lung cancer. Methods Two hundred and sixty - three patients with lung cancer were examined by radionuelied bone imaging and serum CEA,NSE and CYFRA 21 - 1 in the sermn by ELECSYS 2010. Results The sensitivity, differential, veracity of tumor nmrkers ( CEA, NSE, CYFRA 21 - 1 ) and ECT were 88.9% ( 152/171 ), 96.7% ( 89/ 92 ) ,91.6% ( 241/263 ), and it was 65.5% ( 112/171 ) , 87.0% ( 80/92 ) ,73.0% ( 192/263 ) of SPECT, It had significant difference (P 〈 0.01 ) between tumor markers (CEA,NSE,CYFRA21 - 1 ) and ECT vs SPECT. Conclusions ECT and tumor markers has an important value in diagnosis of bone metastasis in lung cancer.
出处
《中国实用医刊》
2009年第22期22-23,共2页
Chinese Journal of Practical Medicine
关键词
肺癌
肿瘤标志物
诊断
Lung cancer
Tumor marker
Diagnosis