高剂量盐酸左氧氟沙星注射液治疗下呼吸道感染的临床分析

Clinical analysis of high-dose levofloxacin hydrochloride for Injection in the treatment of Infection of the lower respiratory tract

目的初步评价高剂量盐酸左氧氟沙星注射液每天1次大剂量给药治疗下呼吸道感染的疗效和安全性。方法前瞻性观察分析高剂量盐酸左氧氟沙星注射液每天600mg、一次给药治疗下呼吸道感染的疗效和不良反应。结果观察期内共治疗下呼吸道感染患者36例，31例有效，有效率86．1％；共检出细菌13株，用药后清除11株（84．6％），2株未清除[1株为耐甲氧西林的金黄色葡萄球菌（MRSA），1株为铜绿假单菌]。36例患者，有3例出现不良反应，其中1例有轻度恶心，1例静脉炎、头昏及腹胀，1例出现兴奋、失眠。结论静脉滴注左氧氟沙星600mg、每天1次给药可以有效治疗临床常见下呼吸道感染，且临床不良反应发生率低，患者耐受性良好，使用方便，值得临床推广应用。

Objective To find out the therapeutic and safety of High-dose levofloxacin hydrochloride for injection in the treatment of Infection of the Lower Respiratory Tract（LRT）. Method A prospective analysis was made concerning the therapeutic effects and adverse reactions of intravenous infusion of levofloxacin hydrochloride for injection 600 mg daily in treatment of infection of LRT. Result The treatment was effective in 31 of the 36 cases,the effective rate being 86.1% ;Among the 13 strains of bacteria isolated, 11 were cleared （ 84.6% ） after the treatment, the remaining 2 strains were methicillin-resistant staphylococcus aureus （MRSA）and pseudomonas aeruginosa, respectively. In 36 cases, there were 3 patients with adverse reactions, of which 1 case with mild nausea, 1 case with phlebitis, dizziness and abdominal distension, 1 cases with excitement and insomnia. Conclusion It was suggested that Intravenous infusion of levofloxacin hydrochloride for injection 600mg daily could be an effective treatment for infection of LRT, and with lower incidence of adverse reactions, patients with well tolerated, convenient to clinical use, and worthy of clinical application.