基质金属蛋白酶-9基因1562C/T分型与2型糖尿病颈动脉粥样硬化的关系被引量：1

Relationship between matrix metalloproteinase-9 1562C/T polymorphisms and carotid artery arteriosclerosis in patients with type 2 diabetes

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摘要目的:研究基质金属蛋白酶-9(MMP-9)基因1562C/T分型与2型糖尿病颈动脉粥样硬化的关系。方法:选取2型糖尿病患者100例,测定患者双侧颈动脉内-中膜厚度(IMT),IMT≥1.3mm为粥样硬化斑块,根据颈动脉有无粥样硬化分为颈动脉硬化组和颈动脉正常组。分别测定这两组患者的MMP-9基因1562C/T分型。结果:颈动脉硬化组与颈动脉正常组CT+TT基因型频率分别为34.1%,16.1%,差异有统计学意义(χ2=4.386,P=0.036)。结论:MMP-9T等位基因与糖尿病颈动脉粥样硬化密切相关。 Objective To investigate the relationship between matrix metalloproteinase-9 （MMP-9） 1562C/T polymorphisms and carotid arteriosclerosis in patients with type 2 diabetes. Methods The carotid intimal-medial thickness （IMT） was determined by type B ultrasound in 100 patients with type2 diabetes. IMT ≥ 1.3 mm was defined as arteriosclerosis. Polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） was used to identify MMP-9 1562C/T polymorphisms. Results The frequency of C/T and T/T genotypes of 1562C/T polymorphism was 34.1% in patients with carotid arteriosclerosis, while in patients without carotid arteriosclerosis the frequency is 16.1%, and the difference is significant between above two groups （X： = 4.386, P = 0.036）. Conclusion The MMP-9 1562C/T polymorphisms are associated with carotid arteriosclerosis in patients with type 2 diabetes.

作者卢杭桢杨纯玉熊玮

机构地区暨南大学第二附属医院深圳市人民医院老年病科

出处《实用医学杂志》 CAS 北大核心 2009年第21期3597-3599,共3页 The Journal of Practical Medicine

关键词糖尿病 2型基因分型基质金属蛋白酶-9 动脉粥样硬化 Diabetes mellitus, type 2 Gene polymorphism Arteriosclerosis

分类号 R587.1 [医药卫生—内分泌] R543 [医药卫生—心血管疾病]

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