橡胶职业暴露与肺癌关系的前瞻性研究 Ⅲ 肺癌危险因素联合作用方式

A Prospective Study on Relationship between Occupational Exposure to Rubber and Lung Cancer ⅢCombined Effects of Risk Factors for Lung Cancer

目的探讨橡胶工人中亚硝胺暴露、吸烟和经济收入低等主要危险因素对肺癌联合作用的模式。方法应用广义相对危险度模型拟合某橡胶厂队列随访资料。结果联合作用下，亚硝胺暴露与吸烟对肺癌危险度为相乘作用形式，亚硝胺暴露与经济收入为相加形式，吸烟与经济收入为相加形式。结论受样本限制，不同模型之间拟合优度的差别较小，但是，在公共卫生实践和生物学机理的认识方面。

Objective To explore the mode of combined effects of main risk factors,such as exposure to nitrosoamine,smoking,low income,et al,on lung cancer in rubber workers.Methods Generalized relative risk model was fitted with data collected from the cohort followedup in a rubber factory.Results Combined effects of exposure to nitrosoamine and smoking on lung cancer in rubber workers presented as multiplicative model,and those of exposure to nitrosoamine and low income,and smoking and low income appeared additive.Conclusion There was only a little difference in goodnessoffit between the models due to the limitation of sample size,but determination of the mode of combined effects of different risk factors played important roles in practice of public health and recognition of its biological mechanism.