整合子与细菌耐药性关系的研究进展

Advances in the Relationship between Integrons and Drug Resistance of Bacteria

细菌耐药性是临床用药的一大难题,对其耐药机制探讨也就成为医学界研究热点,近年研究发现细菌耐药性产生与一种克隆表达载体——整合子密切相关。整合子是一种可移动基因元件,在整合酶的作用下捕获外源基因盒并使之表达,同时整合子又可整合到质粒上,或自身作为转座子的一个组成部分而参与转移,使耐药基因在不同种属间传播,目前整合子已成为革兰阴性杆菌产生耐药性的重要机制。本文就整合子与细菌多重耐药性关系作一综述。

Drug resistance of bacteria is a major problem that harasses clinicians. Thus, many scientists of medical field focus their attention onto the investigation of drug resistance mechanisms. In recent years, some studies indicate that the occurrence of drug resistance is closely linked to cloning and expression vector integron. Integrons is a kind of mobile genetic elements that can capture exogenous gene cassettes and ensure their expression under the action of integrases. At the same time, integrons can be integrated with the plasmid, or participate in the transfer as an integral part of the transposon, so that drug resistance genes can spread among different species. Integrons have become an important drug resistance mechanism of gram-negative bacteria. This paper reviews relationship between integron and multidrug resistance.