摘要
目的观察国产和进口红细胞生成素(rhEPO)治疗中老年慢性肾功能衰竭伴肾性贫血的疗效。方法将38例慢性肾功能衰竭伴肾性贫血患者随机配对,用每周6000单位国产和进口rhEPO皮下注射,治疗12周后观察全血红细胞、血清铁蛋白以及肾功能变化。结果2组在用药过程中血红蛋白(Hb)、红细胞压积(HCT)、红细胞计数(RBC)均逐渐上升,2组患者同周数配对χ2没有显著差别。2组患者治疗的显效率、有效率、总有效率经χ2检验,P>0.05,没有明显差别。在治疗过程中,2组患者血清铁蛋白均有下降。结论国产rhEPO在治疗中老年肾性贫血与进口rhEPO具有相同疗效。
Objective To observe the efficiency of localmade and imported erythropoietin (EPO) in the treatment of anemia due to chronic renal failure. Methods 38 anemia patients due to chronic renal failure were paired randomly into two groups and were given hypodermically localmade or imported EPO 6000U each week for three months.Changes in blood cells,serum ferritin and renal function were observed. Results Hb,HCT and RBC were increased gradually during the course of administration in both grups.No significant difference was observed between them through paried t test at the same period of time.The drug effectiveness of the two group was without significant difference(P>005).Serum ferritin was decreased in both groups. Conclusions Localmade EPO is as effective as the imported one in the treatment of anemia due to renal insufficiency.Ferrum supplement is necessary in the course of EPO treatment.
出处
《实用老年医学》
CAS
1998年第4期161-162,共2页
Practical Geriatrics