脑血栓与脑出血血脂及脂蛋白改变的研究

A Study of Blood Lipid and Lipoprotein in Stroke Patients

为了揭示脂质代谢在动脉血栓性脑梗塞和脑出血之间的并同;及其与不同部位梗塞的关系,评价脂质在脑血管病中的作用。采用酶法对544例不同民族的急性脑血管病(梗塞463例,出血81例)做了血脂分析,并与对照组407例进行比较。结果显示:脑梗塞组和脑出血组的总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL—C)及总胆固醇与高密度脂蛋白胆固醇的比值(TC/HDL—C)均非常显著高于对照组(P<0.001),脑梗塞组的HDL—C非常显著低于对照组(P<O.001);梗塞组和出血组之间,及梗塞组中深穿支闭塞亚组与皮层支闭塞亚组之间各血脂成分对比,无显著差异(P>0.05);单纯脑血管病组及合并高血压、糖尿病、冠心病组分别与正常组对比、单纯脑血管病组与脑血管病各合并症组对比,差异不一,提示血脂异常是脑血管病不可忽视的因素。脂质与脑血管病的关系,复杂而有待于深入研究。

The author measured the blood lipid and lipoprotein levels with enzyme techniques in 544 stroke patients (463 atherothrombotic brain infarction, 81 cevebral haemorrhage) and 407 control subjects in different nations, not only to elucidate the commen and the different in lipid metablism between infarcted and hamorrhage stroke and the associations of lipid metablism with the subtypes of cerebral infarction, but also to evaluate the role of blood lopids and lipoproteins in stroke patients. The results revealed that the stroke groups showed significantly higher total cholesterol (TO, triglyceride (TG), low density lipoprotein cholesterol (LDL - C) and total cholesterol /high density lipoprotein cholesterol (TC/HDL - C) rations (P<0. 001). The infarction groups showed significantly laver HDL -C than in the control group (P<0. 01).