帕金森病病人的异常视网膜电图

Abnormal ERG in patients with Parkinson disease

目的探讨帕金森病（ＰＤ）病人视网膜的电生理改变，以期对ＰＤ诊断有所帮助。方法根据国际临床视觉电生理协会（ＩＳＣＥＶ）制定的标准化方案。对８２例帕金森病病人及４２名健康对照组进行视网膜电图（ｅｌｅｃｔｒｏｒｅｔｉｎｏｇｒａｍ，ＥＲＧ）检查。结果（１）ＰＤ组的ＥＲＧ的ｂ波波幅比对照组低（Ｐ＜０．０１），且波形不规则。（２）ＰＤ病人ＥＲＧ的ｂ波波幅和统一帕金森病量表（ＵＰＤＲＳ）评分呈负相关（Ｐ＜０．０１）。（３）ＰＤ病人常规服药后和停药１天相比ＥＲＧ的ｂ波波幅差异不明显（Ｐ＞０．５），但ＵＰＤＲＳ评分两组差异有显著性意义（Ｐ＜０．０１）。结论ＥＲＧ作为一种眼电生理检查，可客观地反映ＰＤ病人由于视网膜内多巴胺（ＤＡ）变化所致的视网膜电生理改变，且具有较好的稳定性，对ＰＤ的诊断有一定的意义。

Objective To examine 82 patients with Parkinson disease (PD) and 42 nomral people by electroretinogram (ERG). Method The standard scheme made by the International society for clinical electrophysiology of vision was used.Results Patients with PD showed lower b amplitude of ERG with irregular wave shape than the normal controls (P<0.01). Patient′s b amplitude of ERG was negatively interrelated with UPDRS marks (P<0.01). Difference of b amplitude of ERG was not obvious between patients after medication and one day after stopping eating medicine (P>0.5), but UPDRS marks between them were obviously different (P<0.01). Conclusion ERG can objectively reflect the patient′s electrophysical changes of the retina due to DA changes and it may be helpful in diagnosing PD.