丹参多酚注射液治疗冠心病不稳定心绞痛临床研究

Clinical Research on Salviae Miltiorrhizal Polyphenol Injection in Treating UAP of Goronary Artery Disease

目的:观察丹参多酚注射液治疗冠心病心绞痛的有效性及安全性。方法:治疗组用丹参多酚注射液200mg,日1次,静点;对照组用丹参注射液20ml,日1次,静点;两组均14d为1个疗程。结果:治疗组症状改善总有效率为96.67%,较对照组70.0%有显著统计学差异(P(0.05);治疗组心电图改善总有效率为96.67%,对照组为83.33%,两组比较无显著差异(P>0.05);血液流变学各项指标两组治疗前后均有显著统计学差异(P(0.05);其中血浆还原粘度治疗组较对照组有显著统计学差异(P(0.05);其余各项指标两组组间比较无统计学差异(P>0.05)。结论:丹参多酚注射液可以安全有效用于治疗冠心病心绞痛。

Objective： To observe the satety and effectiveness of salriae Miltiorrhizae Polyphenol Injection in treating UAP of coronary Artery Disease. Method ： The treatment group was administered 200 mg Salvia miltiorrhizae polyphenol injection one time per day while the control grocp 20 ml per day. Results： The total effective rate of the treatment group was 96.67% which has remarkable statistical difference（ P 〈 0.05） compared with the control group： the total effective rate of ECG in the treatment group was 96.67% , while the control group 83.33%. The comparision between the two groups had no remarkable difference（ P 〉 0.05 ） ; Indexes of hemorrheology in the two groups had remarkable statistical difference before and after the treatment（P 〈 0.05 ）, furthermore, plasma redncing viscosity in the treatment group had remarkable statistical differenal ; other indeves in the two groups had no statistical difference （ P 〉 0.05 ）. Conclusion： Salviae Miltiorrhizae polyphenol injection can be used to treat UAP of loronary artery disease sately and effectively.