辛硫磷类似物的合成及杀螺活性

Synthesis and Molluscicidal Activity of Phoxim Analogues

为寻找新的高效、低毒灭螺药,以取代苯乙腈为原料,经成肟、硫代磷酰化等反应,制得9个辛硫磷类似物(2a～2i),其结构经元素分析、IR、1H NMR和MS确证。初步杀螺筛选结果表明:化合物2a、2b、2h具有显著的杀螺活性,其半数致死浓度LC50值分别为0.31、0.33、0.38mg/L。

In order to search for novel more effective and less toxic molluscicides,nine new phoxim analogues（2a-2i） were synthesized from substituted phenylacetonitriles by oximation and thiophosphorylation. All compounds were confirmed by elemental analyses,IR,1HNMR and MS. Preliminary biological screening showed that compounds 2a,2b and 2h appeared to have significant molluscicidal activity against Oncomelanis hwpensis snails. The LC50 of the compounds 2a,2b and 2h against snails were 0.31,0.33 and 0.38 mg/L,respectively.