莱姆病诊断技术研究进展

PROGRESS IN DIAGNOSTIC TECHNIQUES OF LYME DISEASE

莱姆病是一种经硬蜱传播的新发人畜共患病,可引起人类的慢性游走性红斑及心脏、神经、关节等多系统受损的疾病,造成病人不同程度的活动障碍和肢体瘫痪。该病在世界范围内广泛分布,我国许多地区是该病的自然疫源地。因此,莱姆病越来越引起人们的重视。伯氏疏螺旋体是引起莱姆病的病原体,因其培养周期长、抗原结构复杂给莱姆病的诊断带来了一定的困难。本文对莱姆病病原体的直接检测、免疫学检测、分子生物学检测和一些新的诊断技术进行了概述。

Lyme disease is a zoonosis which is transmitted by the tick. It can cause erythema chronicum migrans, heart, nerve, joint and other system diseases, and even lead to movement disorder and limb paralysis in humans. Lyme disease is widely distributed in the world. Many areas of China are the natural reservoirs. Borrelia burgdorferi is the pathogen of Lyme disease. Lyme disease is difficult to be diagnosed because Borrelia burgdorferi has long culture cycle and complicated antigenic structure. This paper summarized direct detection, immunological test, molecular biology detection and some new techniques for the diagnosis of Lyme disease.