跑台运动对不同月龄大鼠空间学习和记忆能力的影响

Effect of Treadmill Running on the Ability of Spatial Learning and Memory in Different Age of Rats

目的:探讨跑台运动对不同月龄大鼠空间学习和记忆的影响。方法:实验采用1月龄和13月龄Sprague-Dawley雄性大鼠,随机分为4组(n=10):1月龄安静对照组、1月龄跑台运动组、13月龄安静对照组、13月龄跑台运动组,其中,跑台运动组大鼠以中等强度进行为期1周的跑台运动;然后使用Morris水迷宫,对各组大鼠的定位航行和空间探索能力进行分析。结果:在定位航行试验中,两个运动组大鼠寻找到平台的潜伏期要明显短于相应的安静对照组(P<0.01);1月龄跑台运动组大鼠的潜伏期要少于13月龄跑台运动组(P<0.05)。在空间探索试验中,两个运动组大鼠在原平台象限探索时间百分比要明显多于其相应的安静对照组(P<0.05)。此外,1月龄跑台运动组大鼠穿过原平台的次数明显多于其安静对照组(P<0.05)和13月龄跑台运动组(P<0.05)。13月龄大鼠的两组之间并无差异。结论:跑台运动可以促进大鼠的空间学习和记忆能力,而且,这种作用效果在幼龄期表现得更加明显。

To investigate the effect of treadmill running on spatial learning and memory in different age of rats. Male Sprague-Dawley rats （1 month of age and 13 months of age） were used for the experiment, rats were randomly divided into the 1 month control group, 1 month running group, 13 month control group and 13 month running group （n= 10 in each group）. The running group was made to run on a motor driven treadmill for 1 week. Then the Morris water maze was used to observe learning and memory in rats of four groups. The result showed that, in place navigation training, the latency of rats in both running groups were less than that of rats in respectively control groups（P〈0.01） and the latency of rats in 1 month running group was less than that of rats in 13 month groups （P〈0.05）. In spatial probe test, the percent of swimming time in supposed platform quadrant （D quadrant）in both running groups were more than that of rats in respectively control groups（P〈0.05）, furthermore rats in 1 month running group had more frequency of crossing platform in D quadrant, where the plat- form situated,than that of rats in 1 month control group（P〈0. 05）and 13 month running group（P〈0.05 ）. There was no difference between the both 13 month groups. These findings suggest that treadmill running can enhance the ability of spatial learning and memory in young and adult rats, especially in young rats.