我院262例药品不良反应报告分析

Analysis of 262 cases of adverse drug reactions reported

目的了解该院药品不良反应(ADR)发生的特点,促进临床合理用药。方法对该院收集到的262例ADR报告,按患者年龄、性别、给药途径、ADR程度、药品类型、ADR涉及器官或系统及临床表现等进行分类统计与分析。结果涉及ADR的药品共有262种,抗微生物居首位,其次为中成药;静脉注射引发的ADR为172例(占65.65%);ADR可发生于人体各个系统,但主要为变态反应,以皮肤及其附件损害最为严重,皮肤反应的ADR为183例,是总报告例数的69.85%。结论临床应重视ADR的报告和监测工作,以减少或避免ADR的发生。

Aim To study the characteristics of ADR occurred in our hospital and to promote rational clinical drug use.Method A total of 262ADR reports were collected and statistically analyzed in respect of age and sex of patients,route of administration,ADR degree,drug category,ADR-involving organs and clinical manifestations etc.Results ADR-involving drugs totaled 262 kinds,of which anti-infective agents occupied the first place,followed by Chinese patent medicines.172 ADR cases（65.65%） were induced by intravenous route. ADR occurred systemically and were characterized predominantly by allergic reactions of skin and its appendants, lesions of skin and its appendages accounted for 69.85% of the total ADR cases. Conclusion Importance should be attached to the reporting and monitoring of ADR so as to lessen or avoid the occurrence of ADR in the clinic.