可溶性CD40L对不稳定型心绞痛近期预后的影响

Short-term prognostic value of sCD40L in patients with unstable angina

目的探讨sCD40L对不稳定型心绞痛（UA）近期预后的影响。方法采用酶联免疫吸附法对uA患者49例、稳定型心绞痛（SA）患者20例及对照组20例入院时血浆sCD40L水平进行检测，并对UA患者住院期间及出院后30d的急性不良心血管事件进行随访。结果①UA组患者入院时血浆sCD40L水平[（9．39±1．89）ng／ml]显著高于SA组[（5．92±2．06）ng／ml]（P〈0．01）和正常对照组[（4．91±1．97）ng／ml]（P〈0．01），SA组略高于对照组，但差异无统计学意义。②UA患者中血浆sCD40L增高组住院期间和出院后30d急性不良心血管事件发生率显著高于血浆sCD40L正常组（P〈0．01）。结论UA患者血浆sCD40L显著增高。sCD40L可以作为冠心病易损斑块的血清学标记物，其水平对uA的近期预后有很好的预测价值。

Objective To investigate the short-term prognostic value of the plasma level of sCD40L in patients with unstable angina. Methods The plasma levels of sCD40L of 49 patients with unstable angina, 20 patients with stable angina and 20 controls were measured by enzyme-linked immunosorbent assays（ ELISA ）. The occurrence of adverse acute cardiovascular events of 49 patients with unstable angina was followed-up from hospital- ization to 30 days after hospital discharge. Results （1）The plasma levels of sCD40L were significantly higher in UA group [（9.39±1.89）ng/ml] than in SA group [（5.92±2.06）ng/ml]（P〈0.01） and controls [（4.91±1.97）ng/ml]（P〈 0.01 ]. The difference between SA group and controls was not statistically significant. （2）Among the unstable angina patients, the incidence of adverse acute cardiovascular events were significantly higher in patients with elevated sCD40L level than in patients with normal level of sCD40L. Conclusion The plasma levels of sCD40L in patients with unstable angina were significantly elevated, sCD40L can be considered as the biomarker of vulnerable plaque. The plasma levels of sCD40L can provide valuable short-term prognostic information for unstable angina patients.