卡维地洛治疗慢性心力衰竭临床研究

Clinical Analysis on Chronic Heart Failure Treated with Carvedilol

目的通过检测B-型脑钠肽(BNP)的水平和超声心动图相关参数的变化,观察卡维地洛治疗慢性心力衰竭(CHF)的临床效果。方法将160例入选者(NYHA心功能分级Ⅱ~Ⅲ级,EF<40%)随机分成80例试验组和80例对照组,所有入选病人均充分使用血管紧张素转换酶抑制剂、利尿剂和洋地黄类药物,治疗组加用卡维地洛口服,试验1年。治疗前后查血浆BNP和超声心动图。结果治疗组BNP、左室舒张末内径(LVEDD)、左室收缩末内径(LVESD)、左室射血分数(EF)均有明显改变,治疗前后具有显著性差异。结论CHF患者在常规治疗的基础上加用卡维地洛,可以进一步改善心室功能,降低心肌耗氧量,保护心肌细胞,具有广阔的研究和应用前景。

Objective To discuss the curative effect on CHF treated with carvedilol through detection of BNP level and relative data of Doppler. Methods 160 cases of CHF patient （NYHA Ⅱ - Ⅲ ） were divided into test group and control group. All eases were treated with ACEI, diuretic and digitaloid drug. The test group was added carvedilol for 1 year based on routine therapy. Tile BNP and Doppler were detected before and after therapy. Results The LVEDD, LVESD, EF and BNP were changed obviously after treatment with significant difference. Conclusion The carvedilol and routine therapy could improve HF, decrease myocardial O2 consumption and protect my^ardial cells that might have blight fulure to study.