乳腺癌与肿瘤标志物

Breast cancer and tumor markers

乳腺癌是女性常见的恶性肿瘤之一，其发病率近年来逐渐增高。肿瘤标志物是存在于血液或组织中的一类物质，对肿瘤患者的诊断和治疗具有一定的临床价值。由于对乳腺癌的早期诊断缺乏敏感性并缺少特异性，目前的肿瘤标志物对乳腺癌的早期诊断价值不大。寻找有价值的乳腺癌的早期标志物成为临床上的一个难题。本文综述了肿瘤标志物在乳腺癌的诊断和预后估计等方面的应用，其中包括CA153、CEA、PR和AR，以及新出现的一些标志物如miRNA、hMAM、Midkine等。

Breast cancer is one of the most common cancers in women and has been increasing in the last few years. Tumor markers are usually substances occurring in blood or tissue which might be clinically usable in patients with cancer. Owing to a lack of sensitivity for early disease and lack of specificity, none of the available markers is of much value for the early detection of breast cancer. To identify potential early-stage markers for breast cancer is a difficult problem. Here we summarizes the application of tumor markers in the diagnosis and prognostic prediction in breast cancer, which include CA153,CEA,PR and AR, and recently defined markers such as miRNA,hMAM, Midkine.