盐酸戊乙奎醚、东莨菪碱和阿托品作为胸内手术麻醉前用药的比较

Comparison of penehyclidine hydrochloride,scopolamine and atropineused as premedicate in patients undergoing surgical operation inside the chest

目的将盐酸戊乙奎醚与阿托品作为全麻患者的术前用药,比较两者心血管作用、腺体分泌及术后并发症的影响。方法选择成人胸内手术患者60例随机双盲分为盐酸戊乙奎醚组、东莨菪碱组和阿托品组,每组20例。麻醉前分别肌肉注射盐酸戊乙奎醚0.01mg/kg,东莨菪碱0.006mg/kg,阿托品0.01mg/kg。记录给药后30min、诱导后的BP和HR,观察30min内患者面红口干情况,根据5级警觉/镇静(OAA/S)评分并于术后24、48h测定患者肺功能。结果术前肌肉注射盐酸戊乙奎醚,对心率的影响小,不升高血压,对腺体的抑制作用更强,有效地抑制呼吸道分泌物和口腔腺体分泌物的增加,减少肺部感染和肺不张的发生率,能有效的避免或减少术后并发症,并能增加呼吸频率和流量。结论盐酸戊乙奎醚是术前用药中较为理想的抗胆碱药物,是胸内手术患者麻醉前用药的最佳选择。

Objective To Penehyclidine Hydrochloride and atropine as a preoperative medication of general anesthesia, Comparing the two kinds of drugs on the impact of cardiovascular, gland secretion and postoperative complications. Methods Choice of adult patients with thoracic surgery in 60 cases, randomized, double-blind divided into penehyclidine hydrochloride group, scopolamine and atropine group, 20 cases of each group. Intramuscular injection Penehyclidine Hydrochloride 0. 01 mg/kg, scopolamine 0. 006 mg/kg, atropine 0. 01 mg/kg respectively in each group before anesthesia. Recorded BP and HR in the 30 min after injection, Observe the situation of face flushing and dry mouth in 30 min, determination of 24,48-hour postoperative pul- monary function in accordance with OAA / S score. Conclusion Intramuscular injection penehychdine hydrochloride before surgery, it It is the impact of heart rate of small, it will not or high blood pressure, it has a stronger inhibitory effect on the glands,, and it inhibit the respiratory secretions and oral gland secretions increase effectively. It decrease pulmonary infection and atelectasis incidence, it can be effective to avoid or reduce post-op- erative complications, and can increase the respiratory frequency and flow. It is an ideal anti-cholinergic drugs in the preoperative medication,it is the best choice for the Cardiothoracic surgery in the preoperative medication.