我院门诊抗高血压药物处方分析

Analysis of the prescriptions of the outpatients on lowing blood pressure

目的对中山大学附属第一医院门诊2009年2月份高血压门诊患者降压用药的应用现状和联合用药情况进行处方数据统计,分析医院门诊处方中抗高血压药物之间的相互应用的合理性,旨在提高医院合理选用抗高血压药的水平。方法从门诊2009年2月份全部门诊处方,筛选出含有抗高血压治疗药物的处方,采用WHO推荐的限定日剂量(DDD)、药物利用指数(DUI)及医学统计等方法,对抗高血压药物的应用情况进行了数据统计分析。结果63689张门诊处方中含有抗高血压药处方数为6560张,占处方比例的10.3%。八类抗高血压药物中,在处方中出现频率依次排列为前五位的是钙拮抗剂(CCB)、血管紧张素转换酶抑制药(ACEI)、β-受体阻断药、利尿降压药、血管紧张素Ⅱ受体拮抗药(ARB)。结论各类药物使用情况也基本趋于合理,ACEI类药物的使用应谨慎,特别是联合使用发生的相互作用,而且反应程度为严重的更应引起临床医师的重视。

Objective To analysis the lowing blood pressure medicine in the first affiliated hospital Sun Yat-Sen university of clinic prescriptions and get to know the utilization situation of the antihypertensive medicine in the hospital. Methods Using DDDs analysis and pharmacoeconomic method,we made a statistic analysis of the prescription in our hospital made from Feb in 2009 of outpatients medicine and analyzed the utilization factor of the blood pressure lowing medicine and its rationality as well. The kind of utilization and combined antihypertensive drugs was analyzed. Results The first 5 drugs used in lowing blood pressure medicine were calcium antagonists, ACEI, β-receptor blocking agents, diuretics and angiogenesis converting enzyme inhibitors. The first 3 DDDs of antihypertensive drugs were Felodipine, Monopril and Losarda. DUI of the blood pressure lowing medicine utilized in our hospital is less than 1 or equivalent to 1. The percentage of the treatment with single medicine is 27%, with two is 43%, with three is 19%, with four is 11%. Conclusion Most of prescriptions are appropriate, and the risk of potentially drug interaction in combination medication with ACEI involved should be paid attention to.