男性少精子患者染色体和Y染色体微缺失检查

Chromosomal and Y chromosome microdeletion analysis in patients with oligozoospermia

目的探讨男性少精子患者与外周血染色体异常及Y染色体微缺失的关系和临床意义。方法对150例男性少精子门诊患者同时进行外周血染色体核型分析和Y染色体微缺失检测。对照组为40例已正常生育的男性。结果150例男性少精子患者中,染色体异常30例,异常率20%;Y染色体微缺失8例,缺失率5.3%。对照组40例正常男性均未发现染色体异常和Y染色体微缺失。结论染色体异常或Y染色体微缺失是引起男性少精子的重要原因之一,对临床上少精子患者有必要进行染色体核型分析和Y染色体微缺失检测。

Objective：To investigate the relationship and clinical significance of chromosomal abnormality and Y chromosome microdeletion with Oligozoospermia.Methods：Cytogenetic karyotype and Y chromosome microdeletion analysis were performed in 150 patients and 40 normal fertile men.Results：Of all the 150 patients,30 cases of abnormal chromosome karyotype and 8 cases of Y chromosome microdeletion were found.No such deletion and chromosomal abnormality were observed in 40 normal fertile men.Conclusion：Chromosomal abnormality or Y chromosome microdeletion is one of the important factors that could lead to oligozoospermia.The detection of karyotype and Y microdeletion are necessary for oligozoospermia patients.