摘要
目的分析柳州地区进行母血清产前筛查(以下简称产前筛查)的孕产妇中,胎儿有缺陷的发生情况。方法取孕中期孕妇血清进行甲胎蛋白、游离绒毛膜促性腺激素β-亚基及游离雌三醇等3项指标检测,用专用分析软件计算其风险率,并与B超、羊水、新生儿检查等结果对照。结果高风险孕妇检出率为9.0%,其中21-三体综合征(DS)为7.4%,18-三体综合征为0.4%,神经管畸形(NTD)为0.9%。结论产前筛查和产前诊断是减少出生缺陷发生的重要措施,具有明显的经济效益和社会效益。
Objective：To analyze the fetus defects among detected from prenatal maternal serum screening（hereinafter referred to prenatal screening）in Liuzhou area.Methods：The second-trimester maternal serum alpha-fetoprotein,free β-subunit of human chorionic gonadotropin and free estriol were determined and the risks were analyzed with a special software.The results were compared to the those of the Sonography,amniotic fluid tests and neonatal screening.Results：The detection rate of high-risk pregnant women was 9.0% with 7.4% of trisomy 21 syndrome（DS）,0.4% of trisomy18 syndrome,0.9% of neural tube defects（NTD）.Conclusion：Prenatal screening and prenatal diagnosis is an important measure to reduce birth defects,which has significant economic and social benefits.
出处
《中国优生与遗传杂志》
2009年第11期53-53,65,共2页
Chinese Journal of Birth Health & Heredity
关键词
产前筛查
妊娠中期
出生缺陷
Prenatal screening
Second trimester
Birth defects
