川崎病冠状动脉病变患儿血小板参数变化及临床意义

Changes and clinical significance of platelet parameter of children with kawasaki disease of coronary artery disease

目的探讨川崎病患儿血小板参数的变化与冠状动脉病变的关系。方法对川崎病患儿46名及同期健康儿童30名进行血小板计数(PLT)、平均血小板体积(MPV)、血小板分布宽度(PDW)和血小板压积(PCT)测定。川崎病患儿经心脏彩色超声检查,分为冠状动脉病变组和无冠状动脉病变组。结果川崎病组患儿血小板四项参数急性期、恢复期均显著高于对照组(P<0.01),而恢复期血小板计数、血小板平均体积、血小板压积均显著高于急性期(P<0.01),但急性期血小板分布宽度显著高于恢复期(P<0.01)。川崎病并冠状动脉病变者急性期除PLT外,其余三项参数较无冠状动脉病变者均显著增高(P<0.01),而恢复期四项参数较无冠状动脉病变者均显著增高(P<0.01)。结论血小板参数可作为判断川崎病患儿病情恢复程度和预测冠状动脉病变及指导临床用药的指标。

Objective：To study the clinical significance of platelet parameter changes in kawasaki disease（KD）.Methods：Blood platelet counts（PLT）,Medial platelet volume（MPV）,platelet distribution width（PDW）and platelet crit（PCT）were detected by using the blood assay apparatus of model CD-3700（American）.Children were detected by color Doppler to divide coronary rterial lesion（CAL）and no coronary arterial lesion（NCAL）.Results：Platelet parameter changes in Kawasaki disease in acute period and in recovery period were higher than those of normal children（P〈0.05）,and PLT,PCT,MPV in recovery period were significantly higher than in acute period（P〈0.01）.But PDW in recovery were significantly lower than in acute period（P〈0.01）.excepted PLT,three rest parameters were significantly higher in KD children of CAD than those of no CAD in acute period（P〈0.01）,and four Platelet parameters were significantly higher in KD children of CAD than those of no CAD in recovery period（P〈0.01）.Conclusion：Platelet parameter could be used in judging the recovery degree of KD children,evaluating variety of the patients coronary artery disease and indicating for the clinical therapeutic drug.