儿童医院铜绿假单胞菌检出分析及感染患者的消毒隔离

Analysis of Pseudomonas aeruginosa in Children′s Hospital and Ward Disinfection and Isolation of Infected Patients

目的了解2008年1-9月儿童医院各病区铜绿假单胞菌检出率与加强病区铜绿假单胞菌患者消毒隔离的关系;铜绿假单胞菌对不同类型抗菌药物的耐药情况,以指导临床合理用药。方法收集各病区送检分离的铜绿假单胞菌进行培养鉴定,统计各病区的铜绿假单胞菌检出情况,采用纸片扩散法(K-B法),结果根据美国临床实验室标准化委员会(NCCLS)相关文件判断。结果铜绿假单胞菌对氨苄西林、氨苄西林/舒巴坦、头孢曲松、头孢唑林、复方新诺明的耐药率均>98.00%,对左氧氟沙星及亚胺培南的耐药率最低,约2.00%。结论及时有效地做好病区铜绿假单胞菌的消毒隔离工作,根据药敏结果有针对性地选用抗菌药物,对降低细菌耐药率,有效控制医院感染具有重要意义。

OBJECTIVE To understand the relationship between the detection rate of Pseudomonas aeruginosa in Children＇s Hospital wards from Jan 2008 to Sep 2008 and disinfection and isolation in the department and investigate the change in antimierobial resistance of P. aeruginosa to provide basis for reasonable use of antibiotics in clinical practice. METHODS The clinically isolated P. aeruginosa strains were collected, cultured and identified by paper diffusing method. The results were evaluated according to the relevant documents of NCCLS of USA. RESULTS The resistant rates of P. aeruginosa to Ampicillin, Ampicillin/Sulbactam, ceftriaxone, cefazolin and SMI were higher than 98%. Their resistant rate to Levofloxacin and IMP was the lowest（about 2% or so）. CONCLUSIONS Effective disinfection and isolation of P. aeruginosa should be performed. Selection of antimicrobial drugs should be according to the results of drug susceptibility, reduce the rate of bacterial resistance.