鲍氏不动杆菌医院感染调查及耐药分析

Surveillance for Clinical Distribution and Antimicrobial Resistance of Acinetobacter baummanii

目的调查鲍氏不动杆菌（ABA）对22种抗菌药物的耐药情况。方法回顾性分析了医院分离到的198株鲍氏不动杆菌的临床分布和耐药率的情况。结果医院2007年7月1日～12月31日分离到198株鲍氏不动杆菌，其中痰液171株（86．4％），尿液12株（6．1％），血液10株（5．0％），分泌物5株（2．5％）；对阿米卡星敏感率为75．0％～100．0％。头孢哌酮／舒巴坦敏感率为89．4％～100．0％，其余抗菌药物的敏感率均〈41．7％。结论鲍氏不动杆菌的耐药形势严峻，仅对2种抗菌药物敏感；药敏提示治疗首选，头孢哌酮／舒巴坦和（或）阿米卡星。

OBJECTIVE To investigate the distribution and antimierobial resistance among clinical isolates of Acine- tobacter baumannii （AA） from July 1 to Dect 31 2007 in Haidian Hospital of Beijing. METHODS A retrospective study on clinical distribution and antimicrobial resistance of 22 antibiotics to ABA was undertaken. RESULTS ABA frequently detected out in phlegm specimen with the detection rate of 86.4%. The drug-resistance to SCF and AMK was the lowest. CONCLUSIONS ABA had severe drug-resistance, SCF and AMK keep better activity to ABA. Rational selection and use of antibacterials is important to prevent the appearance of drug-resistance of ABA.