医院内深部真菌感染的临床分析

The Clinical Analysis of Nosocomial Deep Fungal Infections

目的了解医院内真菌感染的临床分布及其危险因素,为预防及治疗院内真菌感染提供依据。方法回顾性分析2008年1月-2009年1月真菌感染患者的临床资料。结果医院内真菌感染部位以呼吸道为主,占72.2%,其次为血液和尿路感染;最常见的真菌感染病原菌是白色假丝酵母菌,占53.3%;高龄患者、严重基础疾病、经验性广谱抗菌药物不规范应用、激素、化疗放疗及侵入性操作等是感染的危险因素。结论应重视医院内真菌感染,通过加强真菌的检测指导临床合理用药,从而有效预防与控制院内真菌感染。

OBJECTIVE To investigate the clinical distributed situation and the risk factors of nosocomial deep fungal infections, to provide the basis for the prevention and the treatment of fungal infections in hospital. METHODS From Jan 2008 to Jan 2009, all clinical data of the patients with fungal infection were reviewed retrospectively. RESULTS The respiratory tract primarily was found to be the most common infective location （72.2%）. Secondary infective locations were the blood and urinary tract. Infections caused by Candida albicans were the most common invasive fungal infections （53.3%）. The causes of these infections were highly associated with risk factors such as age 〉 60 years old, serious foundation disease, abuse application of broadspectrum antibiotics, hormones, chemotherapy and radiotherapy, invasive operations, and so on. CONCLUSIONS We should pay atteution to nosocomial fungal infections and prevent and control them effectively by strengthening the detection of the fungus and antifungus therapy.