半夏泻心汤加味辨证治疗Hp相关性慢性胃炎及其对IL-8的影响

Treatment of Hp-related Chronic Gastritis with Ban xia Xie xin Decoction and Its Influence on IL-8

目的观察半夏泻心汤加味辨证治疗Hp相关性慢性胃炎的临床疗效、复发率,以及其对IL-8变化的影响,探讨半夏泻心汤对胃黏膜的保护作用机制。方法全部病例随机分为治疗组48例,服用半夏泻心汤治疗。对照组42例,给予丽珠胃三联疗法。结果(1)治疗组临床治愈率、显效率及有效率均优于对照组,差异有显著性(P<0.05)。(2)治疗组血清IL-8含量明显下降,与对照组比较差异有显著性(P<0.05),提示半夏泻心汤能明显降低慢性胃炎患者血清中IL-8的水平。(3)治疗1年后随访,治疗组复发率为4.2%,对照组复发率为14.3%,两组比较差异有显著性(P<0.05)。结论半夏泻心汤加味治疗Hp相关性慢性胃炎,方随法变,药因证异,有的放矢,灵活而不离辨证论治的原则,收效颇佳。

Objective To observe the chnical efficacy and relapse rate in the treatment of Hp-related chronic gastritis with Banxia xie xin decoction and its impact on IL-8 and to explore its protective mechanism to the gastric mucosa. Methods All cases were randomly divided into two groups ： 48 cases of the treatment group given Banxia xie xin decoction, and 42 cases of the control group given Lizhuwei therapy. Results （1） The chnical cure rate of the treatment group was better than that of the control group（P〈0.05 ）. （2） The serum IL-8 of the treatment group was significantly decreased compared with the control group（P〈0.05）. Banxia xie xin decoction reduced the serum IL-8 level in the patients with chronic gastritis. （3） The follow-up after one year treatment showed the relapse rate of the treatment group was 4.2% and that of the control group was 14.3%, with a significant difference between the two groups（P〈0.05）. Conclusion The treatment of Hp-related chronic gastritis with Banxia xie xin decoction shows the advantages of better target, flexible regulation of the tang prescription with the change of the condition and good treatment result.